Physiology and Pathology of Novel Forms of Progastrin

Grant number: 509074 | Funding period: 2008 - 2011

Completed

Abstract

Gastrin is a stomach hormone which increases acid secretion and the growth of the stomach and bowel. This growth promoting effect may be involved in a number of cancers especially colon cancer. The different types of gastrins have different effects but we do not know which forms are important and whether all are active. The types and activity of the different gastrins will be investigated using cell lines, animal models and colon cancer patients with the view of establishing new treatments.

Related publications (3)

The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway

O Patel, KM Marshall, G Bramante, GS Baldwin, A Shulkes

2010-12-10

Progastrin is processed to a number of peptides including glycine-extended gastrin, amidated gastrin and the C-terminal flanking p..

Gastrin increases its own synthesis in gastrointestinal cancer cells via the CCK2 receptor

S Kovac, L Xiao, A Shulkes, O Patel, GS Baldwin

2010-11-05

The involvement of the gastrointestinal hormone gastrin in the development of gastrointestinal cancer is highly controversial. Her..

Evolution of gastrointestinal hormones: The cholecystokinin/gastrin family

GS Baldwin, O Patel, A Shulkes

2010-02-01

PURPOSE OF REVIEW: To describe recent advances in our understanding of the evolution of gastrointestinal hormones, with the gastri..

University of Melbourne Researchers

Arthur Shulkes

Oneel Patel Surgery - Austin Health